Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

Ekaterina Polkh avatar Ekaterina Polkhorcid logoNicola Soranzo avatar Nicola SoranzoLeily Rabbani avatar Leily RabbaniFriederike Dündar avatar Friederike DündarGildas Le Corguillé avatar Gildas Le Corguilléorcid logoHelena Rasche avatar Helena Rascheorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoKatarzyna Kamieniecka avatar Katarzyna KamienieckaWilliam Durand avatar William Durandorcid logoCristóbal Gallardo avatar Cristóbal GallardoJoachim Wolff avatar Joachim Wolfforcid logoFlorian Heyl avatar Florian Heylorcid logoHans-Rudolf Hotz avatar Hans-Rudolf HotzVivek Bhardwaj avatar Vivek Bhardwajorcid logoMo Heydarian avatar Mo Heydarianorcid logoMartin Čech avatar Martin ČechVerena Moosmann avatar Verena Moosmannorcid logoSaskia Hiltemann avatar Saskia HiltemannMélanie Petera avatar Mélanie Peteraorcid logoMallory Freeberg avatar Mallory FreebergDevon Ryan avatar Devon Ryanorcid logoLucille Delisle avatar Lucille Delisleorcid logoAnup Kumar avatar Anup Kumarorcid logoYvan Le Bras avatar Yvan Le BrasTorsten Houwaart avatar Torsten Houwaartorcid logoBjörn Grüning avatar Björn Grüningorcid logoBérénice Batut avatar Bérénice BatutFidel Ramirez avatar Fidel Ramirezorcid logoAnika Erxleben avatar Anika Erxlebenorcid logoKhaled Jum'ah avatar Khaled Jum'ahMehmet Tekman avatar Mehmet TekmanNiall Beard avatar Niall Beardorcid logoArmin Dadras avatar Armin Dadrasorcid logoMaria Doyle avatar Maria Doyleorcid logoPavankumar Videm avatar Pavankumar Videmorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoTristan Reynolds avatar Tristan Reynolds

Funding

These individuals or organisations provided funding support for the development of this resource

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Melbourne Bioinformatics
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Australian BioCommons
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de.NBI
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The University of Melbourne
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UFR
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Collaborative Research Centre 992
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ELIXIR Europe