Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

orcid logoAmirhossein Naghsh Nilchi avatar Amirhossein Naghsh NilchiVerena Moosmann avatar Verena MoosmannFidel Ramirez avatar Fidel Ramirezorcid logoYvan Le Bras avatar Yvan Le Brasorcid logoArmin Dadras avatar Armin DadrasMehmet Tekman avatar Mehmet Tekmanorcid logoCristóbal Gallardo avatar Cristóbal Gallardoorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoMaria Doyle avatar Maria DoyleFriederike Dündar avatar Friederike Dündarorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoKhaled Jum'ah avatar Khaled Jum'ahorcid logoHelena Rasche avatar Helena Rascheorcid logoAnika Erxleben avatar Anika ErxlebenVivek Bhardwaj avatar Vivek Bhardwajorcid logoFlorian Heyl avatar Florian Heylorcid logoNicola Soranzo avatar Nicola Soranzoorcid logoBérénice Batut avatar Bérénice Batutorcid logoLucille Delisle avatar Lucille DelisleTorsten Houwaart avatar Torsten Houwaartorcid logoPavankumar Videm avatar Pavankumar VidemWilliam Durand avatar William Durandorcid logoMartin Čech avatar Martin ČechLeily Rabbani avatar Leily Rabbaniorcid logoMo Heydarian avatar Mo HeydarianDevon Ryan avatar Devon Ryanorcid logoAnup Kumar avatar Anup KumarGildas Le Corguillé avatar Gildas Le Corguilléorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoSaskia Hiltemann avatar Saskia Hiltemannorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoBjörn Grüning avatar Björn GrüningJoachim Wolff avatar Joachim WolffNiall Beard avatar Niall BeardMélanie Pétéra avatar Mélanie PétéraEkaterina Polkh avatar Ekaterina Polkhorcid logoMallory Freeberg avatar Mallory Freeberg

Funding

These individuals or organisations provided funding support for the development of this resource

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UFR
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de.NBI
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The University of Melbourne
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Melbourne Bioinformatics
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ELIXIR Europe
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Collaborative Research Centre 992
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Australian BioCommons